PublicationsModeling Human Cytochrome P450 2D6 Metabolism and Drug-Drug Interaction by a Novel PAnel of Knockout and Humanized Mouse Lines. Scheer N, Kapelyukh Y, McEwan J, Beuger V, Stanley LA, Rode A and Wolf CR. (2012) Mol Pharmacol. Quantitative prediction of human pregnane X receptor and cytochrome P450 3A4 mediated drug-drug interaction in a novel multiple humanized mouse line. Hasegawa M, Kapelyukh Y, Tahara H, Seibler J, Rode A, Krueger S, Lee DN, Wolf CR, Scheer N. (2011) Mol Pharmacol. Human constitutive androstane receptor (CAR) and pregnane X receptor (PXR) support the hypertrophic but not he hyperplastic response to the murine non-genotoxic hepatocarinogens phenobarbital and chlordane in vivo. ., Ross, J., Plummer, S., Rode, A., Scheer, N S., Vogel, O., Wolf, C.R., and Elcombe, C., (2010) epub J. Tox. Sci..
- In vivo responses of the human and murine pregnane X receptor to dexamethasone in mice. Scheer N, Ross J, Kapelyukh Y, Rode A and Wolf CR, (2009)
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- A Novel Panel of Mouse Models to Evaluate the Role of Human Pregnane X Receptor and Constitutive Androstane Receptor in Drug Response. Scheer N, Ross J, Rode A, Zevnik B, Niehaves S, Faust N, and Wolf CR ,(2008)The Journal of Clinical Investigation 118(9), pp3228–3239.
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- Time-Dependent and Compartment-Specific Effects of In Utero Exposure to Di(n-butyl) Phthalate on Gene/Protein Expression in the Fetal Rat Testis as Revealed byTranscription Profiling and Laser Capture Microdissection. Plummer S, Sharpe RM, Hallmark N, Mahood IK, Elcombe C, (2007)Toxicological Sciences 97(2), pp520–532.
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Poster Presentations (2008-2009) SOT 48th Annual meeting & ToxExpo™, 15-19th March 2009 - Transcript Profiling of PXR and CAR Knock-out and Humanized Mouse Liver Provides Insight into Endogenous Roles of the Human PXR/CAR Isoforms.
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ECETOC Annual Technical meeting, Brussels, 9-10th June 2009 - Human Constitutive Androstane Receptor (CAR) Supports The Hypertrophic but Not the Hyperplastic Response to the Murine Non-genotoxic Carcinogen Phenobarbital in vivo
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British Toxiocology Society Annual Congress, University of Warwick, Coventry, 22-25th March 2009 - An In vitro Model for the Prediction of Chemical Metabolism and Toxicity
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10th European ISSX meeting, Vienna, Austria, 18-21st May 2008 - A Novel Panel of Double "Humanised" & Knockout PXR and CAR Mouse Models
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Oral Presentations 2007 British Toxicology Society Perfluorooctanoic Acid Workshop, Shrigley Hall, Cheshire, 5th-6th November 2007 Dr Cliff Elcombe - Overview of Mechanistic Research on Perfluorinated Alkyl Acids with Emphasis on the Potential Value of New Technologies and Bio-Informatics in Elucidating Modes of Action.
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Toxicogenomics Meeting, Nice, 1st October 2007 Dr Simon Plummer - Laser Microdissection Targetted Transcription profiling and Pathways Analysis for Mechanism Based Hazard Assessment.
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Poster Presentations (2007) British Toxiocology Society Annual Congress, University of Surrey, Guildford, 15-18th April 2007 - Comparison of Gene Expression Changes in Whole Pancreas With Isolated Pancreatic acinar cells of rats fed diets containing Wyeth 14,643 or Ammonium Perfluorooctanoate (APFO)
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- Characterisation of APFO Induced Hepatomegaly in Rats
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Society of Toxicology, 46th Annual Meeting and Tox Expo, Charlotte, NC, 25-29th March 2007 - Improved "Humanised" PXR and CAR Mouse Models
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- In vitro metabolites of Arylamine hair dyes in human hepatic microsomes and human hepatocyte
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- Comparison of 1-colour and 2-colour methods for microarray-based transcription profiling analysis with laser captured micro-dissected analysis
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- Identification of region specific gene expression changes and signalling pathways affected by Di-butyl-phthalate in foetal rat testes
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General Poster Presentations - Comparison of 1 cycle and 2 cycle RNA Labelling Methods for Microarray-based Transcription Profiling Analysis with Laser Capture Microdissected Samples
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- The Effects of Ammonium Perfluorooctanoate (APFO) on the Transcriptional Profile of Pancreas and Liver of Male Rats
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- High Throughput Inhibition Screening of Five Major Human cytochrome P450 Enzymes using an In vitro Substrate cocktail
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- Hepatic Metabolism of Aromatic Amine Hair Dye Components as Compared with that of 2-Aminofluorine
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- Novel PXR/CAR Humanised Mouse Models to predict Human Drug Disposition and Toxicity
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- Different Effects of PPAR alpha and PPAR gamma Agonists on Hepatocytes S-phase and Apoptosis
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